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Sulforaphane inhibits blue light-induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelial cells.
Yang, Po-Min; Cheng, Kai-Chun; Huang, Jing-Yao; Wang, Shih-Yun; Lin, Yung-Ni; Tseng, Yen-Tzu; Hsieh, Chia-Wen; Wung, Being-Sun.
Afiliación
  • Yang PM; Department of Ophthalmology, Chiayi Christian Hospital, Chiayi 60002, Taiwan.
  • Cheng KC; Department of Ophthalmology, Kaohsiung Municipal Hsiao-kang Hospital, Kaohsiung 81267, Taiwan; Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan; Department of Ophthalmology, college of medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
  • Huang JY; Department of Microbiology, Immunology and Biopharmaceuticals, National Chiayi University, Chiayi 60002, Taiwan.
  • Wang SY; Department of Microbiology, Immunology and Biopharmaceuticals, National Chiayi University, Chiayi 60002, Taiwan.
  • Lin YN; Department of Microbiology, Immunology and Biopharmaceuticals, National Chiayi University, Chiayi 60002, Taiwan.
  • Tseng YT; Department of Microbiology, Immunology and Biopharmaceuticals, National Chiayi University, Chiayi 60002, Taiwan.
  • Hsieh CW; Department of Microbiology, Immunology and Biopharmaceuticals, National Chiayi University, Chiayi 60002, Taiwan.
  • Wung BS; Department of Microbiology, Immunology and Biopharmaceuticals, National Chiayi University, Chiayi 60002, Taiwan. Electronic address: bswung@mail.ncyu.edu.tw.
Toxicol Appl Pharmacol ; 421: 115545, 2021 06 15.
Article en En | MEDLINE | ID: mdl-33894213
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Sulfóxidos / Apoptosis / Isotiocianatos / Células Epiteliales / Factor 2 Relacionado con NF-E2 / Epitelio Pigmentado de la Retina / Sirtuina 1 / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Antiinflamatorios Límite: Humans Idioma: En Revista: Toxicol Appl Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Taiwán
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Sulfóxidos / Apoptosis / Isotiocianatos / Células Epiteliales / Factor 2 Relacionado con NF-E2 / Epitelio Pigmentado de la Retina / Sirtuina 1 / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Antiinflamatorios Límite: Humans Idioma: En Revista: Toxicol Appl Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: Taiwán