The role of PTEN signaling in synaptic function: Implications in autism spectrum disorder.
Neurosci Lett
; 759: 136015, 2021 08 10.
Article
en En
| MEDLINE
| ID: mdl-34111509
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulates several cellular processes including survival, proliferation, and metabolism. In the brain, PTEN is a key modulator of synaptic function, and is involved in regulating synaptogenesis, connectivity, and synaptic plasticity. Herein we discuss how alterations in PTEN can disturb these mechanisms, thus compromising normal synaptic function and consequently contributing to behavioral and cognitive phenotypes observed in autism spectrum disorder (ASD). As the role of PTEN in synaptic function is linked to ASD, a deeper understanding of this interaction will shed light on the pathological mechanisms involved in ASD, contributing to the development of new therapies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfohidrolasa PTEN
/
Trastorno del Espectro Autista
/
Plasticidad Neuronal
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neurosci Lett
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Irlanda