Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma.

Gao, Lin; Xia, Liliang; Ji, Wenxiang; Zhang, Yanshuang; Xia, Weiliang; Lu, Shun

Gao, Lin; Xia, Liliang; Ji, Wenxiang; Zhang, Yanshuang; Xia, Weiliang; Lu, Shun.

Afiliación

Gao L; Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 Huaihai West Road, Shanghai 200030, PR China.
Xia L; Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 Huaihai West Road, Shanghai 200030, PR China.
Ji W; Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 Huaihai West Road, Shanghai 200030, PR China.
Zhang Y; State Key Laboratory of Oncogenes and Related Genes, School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 HuashanRoad, Shanghai 200030, PR China.
Xia W; State Key Laboratory of Oncogenes and Related Genes, School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 HuashanRoad, Shanghai 200030, PR China. Electronic address: wlxia@sjtu.edu.cn.
Lu S; Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 Huaihai West Road, Shanghai 200030, PR China. Electronic address: shunlu@sjtu.edu.cn.

Transl Oncol ; 14(9): 101148, 2021 Sep.

Article en En | MEDLINE | ID: mdl-34130052

Palabras clave

CDK5; Immunotherapy; Lung cancer; PD-L1; Ubiquitination

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Transl Oncol Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

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