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Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability.
Bai, Bing; Belovodskiy, Alexandr; Hena, Mostofa; Kandadai, Appan Srinivas; Joyce, Michael A; Saffran, Holly A; Shields, Justin A; Khan, Muhammad Bashir; Arutyunova, Elena; Lu, Jimmy; Bajwa, Sardeev K; Hockman, Darren; Fischer, Conrad; Lamer, Tess; Vuong, Wayne; van Belkum, Marco J; Gu, Zhengxian; Lin, Fusen; Du, Yanhua; Xu, Jia; Rahim, Mohammad; Young, Howard S; Vederas, John C; Tyrrell, D Lorne; Lemieux, M Joanne; Nieman, James A.
Afiliación
  • Bai B; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Belovodskiy A; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Hena M; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Kandadai AS; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Joyce MA; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Saffran HA; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Shields JA; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Khan MB; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Arutyunova E; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Lu J; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Bajwa SK; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Hockman D; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Fischer C; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Lamer T; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Vuong W; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
  • van Belkum MJ; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Gu Z; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
  • Lin F; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Du Y; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
  • Xu J; Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
  • Rahim M; Li Ka Shing Applied Virology Institute, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Young HS; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
  • Vederas JC; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
  • Tyrrell DL; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
  • Lemieux MJ; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
  • Nieman JA; Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
J Med Chem ; 65(4): 2905-2925, 2022 02 24.
Article en En | MEDLINE | ID: mdl-34242027
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Inhibidores de Cisteína Proteinasa / Peptidomiméticos / Proteasas 3C de Coronavirus / SARS-CoV-2 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Inhibidores de Cisteína Proteinasa / Peptidomiméticos / Proteasas 3C de Coronavirus / SARS-CoV-2 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Canadá