Dietary exposure assessment to macrolide antimicrobial residues through infant formulas marketed in Brazil.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
; 38(10): 1672-1688, 2021 Oct.
Article
en En
| MEDLINE
| ID: mdl-34254896
Macrolides are critically important antimicrobials for both human and animal health and should be prioritized in risk assessments, as inappropriate use may result in antimicrobial resistance. The antimicrobials erythromycin, oleandomycin, spiramycin, tilmicosin and tylosin were analysed in infant formula samples by HPLC-MS/MS using a validated analytical method based on a modified QuEChERS extraction. The results of the occurrence study were employed to perform a dietary exposure assessment of infants to residues. In a total of 30 analysed samples, 73% contained spiramycin residues and 27%, tilmicosin residues. Calculated daily intakes ranged from 1.47 × 10-6 to 2.71 × 10-4 mg kg-1 body weight considering all analytes, representing 0.01-0.59% of acceptable daily intakes. The results of the dietary exposure assessment were all below acceptable daily intakes, indicating low potential health concerns. However, according to Brazilian regulations, infant formulas containing residues of one or more of the investigated analytes were deemed as non-compliant.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Contaminación de Alimentos
/
Macrólidos
/
Fórmulas Infantiles
/
Exposición Dietética
/
Antibacterianos
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
/
Infant
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Reino Unido