Drugging the 'undruggable'. Therapeutic targeting of protein-DNA interactions with the use of computer-aided drug discovery methods.

Radaeva, Mariia; Ton, Anh-Tien; Hsing, Michael; Ban, Fuqiang; Cherkasov, Artem

Radaeva, Mariia; Ton, Anh-Tien; Hsing, Michael; Ban, Fuqiang; Cherkasov, Artem.

Afiliación

Radaeva M; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.
Ton AT; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.
Hsing M; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.
Ban F; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.
Cherkasov A; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada. Electronic address: acherkasov@prostatecentre.com.

Drug Discov Today ; 26(11): 2660-2679, 2021 11.

Article en En | MEDLINE | ID: mdl-34332092

Asunto(s)

Antineoplásicos/uso terapéutico; ADN/metabolismo; Diseño de Fármacos; Neoplasias/tratamiento farmacológico; Factores de Transcripción/metabolismo; Proteínas de Unión al ADN/metabolismo; Humanos; Terapia Molecular Dirigida; Neoplasias/genética

Palabras clave

AI; Cancer; Computer-aided drug discovery; Drugs; ProteinDNA interactions; Transcription factor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / ADN / Diseño de Fármacos / Neoplasias / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Drug Discov Today Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido

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