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Novel quinolone derivatives targeting human dihydroorotate dehydrogenase suppress Ebola virus infection in vitro.
Gong, Mingli; Yang, Yiqing; Huang, Yi; Gan, Tianyu; Wu, Yue; Gao, Hongying; Li, Qianqian; Nie, Jianhui; Huang, Weijin; Wang, Youchun; Zhang, Rong; Zhong, Jin; Deng, Fei; Rao, Yu; Ding, Qiang.
Afiliación
  • Gong M; School of Medicine, Tsinghua University, Beijing, 100084, China.
  • Yang Y; School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, China.
  • Huang Y; Wuhan National Biosafety Laboratory, Chinese Academy of Science, Wuhan, 43007, China.
  • Gan T; CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
  • Wu Y; School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, China.
  • Gao H; School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, China.
  • Li Q; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Beijing, 102629, China.
  • Nie J; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Beijing, 102629, China.
  • Huang W; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Beijing, 102629, China.
  • Wang Y; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC) and WHO Collaborating Center for Standardization and Evaluation of Biologicals, Beijing, 102629, China.
  • Zhang R; MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of BasicMedical Sciences, Fudan University, Shanghai, 200032, China.
  • Zhong J; CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
  • Deng F; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
  • Rao Y; School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, China. Electronic address: yrao@tsinghua.edu.cn.
  • Ding Q; School of Medicine, Tsinghua University, Beijing, 100084, China. Electronic address: qding@tsinghua.edu.cn.
Antiviral Res ; 194: 105161, 2021 10.
Article en En | MEDLINE | ID: mdl-34391783
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Replicación Viral / Quinolonas / Ebolavirus / Dihidroorotato Deshidrogenasa Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Antiviral Res Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Replicación Viral / Quinolonas / Ebolavirus / Dihidroorotato Deshidrogenasa Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Antiviral Res Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos