Development of a fluorogenic ADAMTS-7 substrate.

Santamaria, Salvatore; Buemi, Frederic; Nuti, Elisa; Cuffaro, Doretta; De Vita, Elena; Tuccinardi, Tiziano; Rossello, Armando; Howell, Steven; Mehmood, Shahid; Snijders, Ambrosius P; de Groot, Rens

Santamaria, Salvatore; Buemi, Frederic; Nuti, Elisa; Cuffaro, Doretta; De Vita, Elena; Tuccinardi, Tiziano; Rossello, Armando; Howell, Steven; Mehmood, Shahid; Snijders, Ambrosius P; de Groot, Rens.

Afiliación

Santamaria S; Department of Immunology and Inflammation, Imperial College London, London, UK.
Buemi F; Department of Immunology and Inflammation, Imperial College London, London, UK.
Nuti E; Department of Pharmacy, University of Pisa, Pisa, Italy.
Cuffaro D; Department of Pharmacy, University of Pisa, Pisa, Italy.
De Vita E; Department of Pharmacy, University of Pisa, Pisa, Italy.
Tuccinardi T; Department of Pharmacy, University of Pisa, Pisa, Italy.
Rossello A; Department of Pharmacy, University of Pisa, Pisa, Italy.
Howell S; Proteomics Science Technology Platform, The Francis Crick Institute, London, UK.
Mehmood S; Proteomics Science Technology Platform, The Francis Crick Institute, London, UK.
Snijders AP; Proteomics Science Technology Platform, The Francis Crick Institute, London, UK.
de Groot R; Department of Immunology and Inflammation, Imperial College London, London, UK.

J Enzyme Inhib Med Chem ; 36(1): 2160-2169, 2021 Dec.

Article en En | MEDLINE | ID: mdl-34587841

Asunto(s)

Desarrollo de Medicamentos; Colorantes Fluorescentes/farmacología; Inhibidores de Proteasas/farmacología; Proteína ADAMTS7/antagonistas & inhibidores; Proteína ADAMTS7/metabolismo; Relación Dosis-Respuesta a Droga; Transferencia Resonante de Energía de Fluorescencia; Colorantes Fluorescentes/síntesis química; Colorantes Fluorescentes/química; Humanos; Estructura Molecular; Inhibidores de Proteasas/síntesis química; Inhibidores de Proteasas/química; Relación Estructura-Actividad; Especificidad por Sustrato

Palabras clave

ADAMTS-7; ADAMTS7; activity assay; coronary artery disease; inhibitor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Colorantes Fluorescentes / Desarrollo de Medicamentos Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido

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