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Association of different fractionation schedules for prophylactic cranial irradiation with toxicity and brain metastases-free survival in stage III non-small cell lung cancer: A pooled analysis of individual patient data from three randomized trials.
Witlox, Willem J A; Ramaekers, Bram L T; Lacas, Benjamin; Pechoux, Cecile Le; Sun, Alexander; Wang, Si-Yu; Hu, Chen; Redman, Mary; van der Noort, Vincent; Li, Ning; Guckenberger, Matthias; van Tinteren, Harm; Groen, Harry J M; Joore, Manuela A; De Ruysscher, Dirk K M.
Afiliación
  • Witlox WJA; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre (MUMC), The Netherlands; Department of Radiation Oncology (Maastro Clinic), Maastricht University Medical Centre (MUMC), The Netherlands. Electronic address: willem.witlox@mumc.nl.
  • Ramaekers BLT; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre (MUMC), The Netherlands.
  • Lacas B; Department of Biostatistics and Epidemiology, Gustave Roussy, University Paris-Saclay, Villejuif, France; Oncostat U1018, Inserm, University Paris-Saclay, labeled Ligue Contre le Cancer, Villejuif, France.
  • Pechoux CL; Department of Radiation Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France.
  • Sun A; Princess Margaret Cancer Centre, Department of Radiation Oncology, University of Toronto, Canada.
  • Wang SY; Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Hu C; NRG Oncology Statistics and Data Management Center, Philadelphia, United States; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, United States.
  • Redman M; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, United States.
  • van der Noort V; Department of Biometrics, Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands.
  • Li N; Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Guckenberger M; Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Switzerland.
  • van Tinteren H; Trial and Data Center, Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.
  • Groen HJM; Department of Pulmonary Diseases, University of Groningen and University Medical Center Groningen, The Netherlands.
  • Joore MA; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre (MUMC), The Netherlands; Care and Public Health Research Institute (CAPHRI), Maastricht University, The Netherlands.
  • De Ruysscher DKM; Department of Radiation Oncology (Maastro Clinic), Maastricht University Medical Centre (MUMC), The Netherlands.
Radiother Oncol ; 164: 163-166, 2021 11.
Article en En | MEDLINE | ID: mdl-34619235
We assessed the impact of different PCI fractionation schedules (30 Gy in 10 versus 15 fractions) on brain metastases-free survival (BMFS) and toxicity in stage III NSCLC. Our results suggest that 30 Gy in 10 fractions is associated with increased toxicity, while no conclusive evidence of improving BMFS was seen with this schedule.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Carcinoma de Pulmón de Células no Pequeñas / Intervención Coronaria Percutánea / Neoplasias Pulmonares Tipo de estudio: Clinical_trials / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Radiother Oncol Año: 2021 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Carcinoma de Pulmón de Células no Pequeñas / Intervención Coronaria Percutánea / Neoplasias Pulmonares Tipo de estudio: Clinical_trials / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Radiother Oncol Año: 2021 Tipo del documento: Article Pais de publicación: Irlanda