suPAR, a Circulating Kidney Disease Factor.

Wei, Changli; Spear, Ryan; Hahm, Eunsil; Reiser, Jochen

Wei, Changli; Spear, Ryan; Hahm, Eunsil; Reiser, Jochen.

Afiliación

Wei C; Department of Medicine, Rush University Medical Center, Chicago, IL, United States.
Spear R; Department of Medicine, Rush University Medical Center, Chicago, IL, United States.
Hahm E; Department of Medicine, Rush University Medical Center, Chicago, IL, United States.
Reiser J; Department of Medicine, Rush University Medical Center, Chicago, IL, United States.

Front Med (Lausanne) ; 8: 745838, 2021.

Article en En | MEDLINE | ID: mdl-34692736

RESUMEN

Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to many disease states. In this mini-review, we discuss suPAR as a key circulating molecule mediating kidney disease with a particular focus on differently spliced isoforms.

Palabras clave

isoform; kidney; proteinuric disease; suPAR; uPAR

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Med (Lausanne) Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

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