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Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Ju, Han; Murugan, N Arul; Hou, Lingxin; Li, Ping; Guizzo, Laura; Zhang, Ying; Bertagnin, Chiara; Kong, Xiujie; Kang, Dongwei; Jia, Ruifang; Ma, Xiuli; Du, Ruikun; Poongavanam, Vasanthanathan; Loregian, Arianna; Huang, Bing; Liu, Xinyong; Zhan, Peng.
Afiliación
  • Ju H; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P.R. China.
  • Murugan NA; Department of Computer Science, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm SE-10044 , Sweden.
  • Hou L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P.R. China.
  • Li P; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
  • Guizzo L; Department of Molecular Medicine, University of Padova, Via Gabelli 63, Padova 35121, Italy.
  • Zhang Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P.R. China.
  • Bertagnin C; Department of Molecular Medicine, University of Padova, Via Gabelli 63, Padova 35121, Italy.
  • Kong X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P.R. China.
  • Kang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P.R. China.
  • Jia R; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P.R. China.
  • Ma X; Institute of Poultry Science, Shandong Academy of Agricultural Sciences, 202 North Gongye Road, Jinan, Shandong 250100, China.
  • Du R; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
  • Poongavanam V; Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Odense M DK-5230, Denmark.
  • Loregian A; Department of Molecular Medicine, University of Padova, Via Gabelli 63, Padova 35121, Italy.
  • Huang B; Institute of Poultry Science, Shandong Academy of Agricultural Sciences, 202 North Gongye Road, Jinan, Shandong 250100, China.
  • Liu X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P.R. China.
  • Zhan P; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P.R. China.
J Med Chem ; 64(24): 17992-18009, 2021 12 23.
Article en En | MEDLINE | ID: mdl-34735766
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Subtipo H5N1 del Virus de la Influenza A / Oseltamivir / Neuraminidasa Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Subtipo H5N1 del Virus de la Influenza A / Oseltamivir / Neuraminidasa Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos