Microbial transformation of pentacyclic triterpenes for anti-inflammatory agents on the HMGB1 stimulated RAW 264.7 cells by Streptomyces olivaceus CICC 23628.

Zhu, Yuyuan; Shen, Pingping; Wang, Jiayi; Jiang, Xuewa; Wang, Wei; Raj, Richa; Ge, Haixia; Wang, Weiwei; Yu, Boyang; Zhang, Jian

Zhu, Yuyuan; Shen, Pingping; Wang, Jiayi; Jiang, Xuewa; Wang, Wei; Raj, Richa; Ge, Haixia; Wang, Weiwei; Yu, Boyang; Zhang, Jian.

Afiliación

Zhu Y; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Shen P; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Wang J; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Jiang X; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Wang W; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Raj R; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.
Ge H; School of Life Sciences, Huzhou University, Huzhou 313000, PR China.
Wang W; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, PR China.
Yu B; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, PR China.
Zhang J; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, PR China; ZhenPing Expert Workstation for Zhang Jian, Zhenping, Ankang, Shaanxi

Bioorg Med Chem ; 52: 116494, 2021 12 15.

Article en En | MEDLINE | ID: mdl-34800877

Asunto(s)

Antiinflamatorios/farmacología; Proteína HMGB1/antagonistas & inhibidores; Triterpenos Pentacíclicos/farmacología; Streptomyces/metabolismo; Animales; Antiinflamatorios/química; Antiinflamatorios/metabolismo; Biotransformación; Células Cultivadas; Relación Dosis-Respuesta a Droga; Proteína HMGB1/metabolismo; Ratones; Estructura Molecular; Óxido Nítrico/antagonistas & inhibidores; Óxido Nítrico/biosíntesis; Triterpenos Pentacíclicos/química; Triterpenos Pentacíclicos/metabolismo; Células RAW 264.7; Relación Estructura-Actividad

Palabras clave

3,4-seco-triterpenes; Anti-inflammatory activity; Biotransformation; High mobility group box-1 protein; Pentacyclic triterpenes; Streptomyces olivaceus CICC 23628

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptomyces / Proteína HMGB1 / Triterpenos Pentacíclicos / Antiinflamatorios Límite: Animals Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido

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