Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.

Bresinsky, Merlin; Strasser, Jessica M; Vallaster, Bernadette; Liu, Peng; McCue, William M; Fuller, Jessica; Hubmann, Alexander; Singh, Gurpreet; Nelson, Kathryn M; Cuellar, Matthew E; Wilmot, Carrie M; Finzel, Barry C; Ashe, Karen H; Walters, Michael A; Pockes, Steffen

Bresinsky, Merlin; Strasser, Jessica M; Vallaster, Bernadette; Liu, Peng; McCue, William M; Fuller, Jessica; Hubmann, Alexander; Singh, Gurpreet; Nelson, Kathryn M; Cuellar, Matthew E; Wilmot, Carrie M; Finzel, Barry C; Ashe, Karen H; Walters, Michael A; Pockes, Steffen.

Afiliación

Bresinsky M; Institute of Pharmacy, University of Regensburg, Universitätsstraße 31, Regensburg 93053, Germany.
Strasser JM; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Vallaster B; Institute of Pharmacy, University of Regensburg, Universitätsstraße 31, Regensburg 93053, Germany.
Liu P; Department of Neurology, University of Minnesota, 2101 6th Street SE, Minneapolis 55455, United States.
McCue WM; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Fuller J; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Hubmann A; Institute of Pharmacy, University of Regensburg, Universitätsstraße 31, Regensburg 93053, Germany.
Singh G; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Nelson KM; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Cuellar ME; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Wilmot CM; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Finzel BC; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Ashe KH; Department of Neurology, University of Minnesota, 2101 6th Street SE, Minneapolis 55455, United States.
Walters MA; Department of Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Pockes S; Institute of Pharmacy, University of Regensburg, Universitätsstraße 31, Regensburg 93053, Germany.

ACS Pharmacol Transl Sci ; 5(1): 20-40, 2022 Jan 14.

Article en En | MEDLINE | ID: mdl-35059567

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: ACS Pharmacol Transl Sci Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

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