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Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies.
Martelli, Felipe; Hernandes, Natalia H; Zuo, Zhongyuan; Wang, Julia; Wong, Ching-On; Karagas, Nicholas E; Roessner, Ute; Rupasinghe, Thusita; Robin, Charles; Venkatachalam, Kartik; Perry, Trent; Batterham, Philip; Bellen, Hugo J.
Afiliación
  • Martelli F; School of BioSciences, The University of Melbourne, Melbourne, Australia.
  • Hernandes NH; School of BioSciences, The University of Melbourne, Melbourne, Australia.
  • Zuo Z; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
  • Wang J; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
  • Wong CO; Department of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center, Houston, United States.
  • Karagas NE; Department of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center, Houston, United States.
  • Roessner U; School of BioSciences, The University of Melbourne, Melbourne, Australia.
  • Rupasinghe T; School of BioSciences, The University of Melbourne, Melbourne, Australia.
  • Robin C; School of BioSciences, The University of Melbourne, Melbourne, Australia.
  • Venkatachalam K; Department of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center, Houston, United States.
  • Perry T; School of BioSciences, The University of Melbourne, Melbourne, Australia.
  • Batterham P; School of BioSciences, The University of Melbourne, Melbourne, Australia.
  • Bellen HJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Elife ; 112022 02 22.
Article en En | MEDLINE | ID: mdl-35191376
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Central / Especies Reactivas de Oxígeno / Macrólidos / Metabolismo de los Lípidos / Lisosomas Límite: Animals Idioma: En Revista: Elife Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Central / Especies Reactivas de Oxígeno / Macrólidos / Metabolismo de los Lípidos / Lisosomas Límite: Animals Idioma: En Revista: Elife Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido