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Targeting HIF-1α abrogates PD-L1-mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues.
Bailey, Christopher M; Liu, Yan; Liu, Mingyue; Du, Xuexiang; Devenport, Martin; Zheng, Pan; Liu, Yang; Wang, Yin.
Afiliación
  • Bailey CM; Division of Immunotherapy, Institute of Human Virology, Department of Surgery and Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Liu Y; Institute of Biomedical Sciences, The George Washington University School of Medicine & Health Sciences, Washington DC, USA.
  • Liu M; Division of Immunotherapy, Institute of Human Virology, Department of Surgery and Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Du X; Division of Immunotherapy, Institute of Human Virology, Department of Surgery and Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Devenport M; Division of Immunotherapy, Institute of Human Virology, Department of Surgery and Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Zheng P; Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong University, Jinan, China.
  • Liu Y; OncoC4, Inc, Rockville, Maryland, USA.
  • Wang Y; Division of Immunotherapy, Institute of Human Virology, Department of Surgery and Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.
J Clin Invest ; 132(9)2022 05 02.
Article en En | MEDLINE | ID: mdl-35239514

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Equinomicina / Subunidad alfa del Factor 1 Inducible por Hipoxia / Neoplasias Límite: Animals Idioma: En Revista: J Clin Invest Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Equinomicina / Subunidad alfa del Factor 1 Inducible por Hipoxia / Neoplasias Límite: Animals Idioma: En Revista: J Clin Invest Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos