OPEC study: An international multicenter study of ovarian preservation in endometrial cancers.
Int J Gynaecol Obstet
; 159(2): 550-556, 2022 Nov.
Article
en En
| MEDLINE
| ID: mdl-35323994
ABSTRACT
OBJECTIVE:
To evaluate the feasibility and oncological safety of ovarian preservation in early stage endometrial adenocarcinoma (EC) patients aged 40 and below.METHODS:
A total of 11 institutions from eight countries participated in the study. 169 of 5898 patients aged ≤40 years were eligible for the study. Patients with EC treated between March 2007 and January 2019 were retrospectively assessed.RESULTS:
The median duration of follow-up after EC diagnosis was 59 months (4-187). Among 169 participants, ovarian preservation surgery (OPS) was performed in 54 (31.9%), and BSO was performed in 115 (68.1%) patients. Although patients younger than 30 years of age were more likely to have OPS than patients aged 30 to 40 years (20.4% vs. 9.6%, P = 0.021), there was no significant difference by the mean age. There were no other relevant baseline differences between OPS and BSO groups. The Kaplan-Meier analysis revealed no difference in either the overall survival (P = 0.955) or recurrence-free survival (P = 0.068) among patients who underwent OPS, and BSO.CONCLUSION:
OPS appears to be safe without having any adverse impact on survival in women aged ≤40 years with FIGO Stage I EC.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Neoplasias Endometriales
/
Preservación de la Fertilidad
Tipo de estudio:
Observational_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Int J Gynaecol Obstet
Año:
2022
Tipo del documento:
Article
País de afiliación:
Turquía