Mefloquine induces ER stress and apoptosis in BRAFi-resistant A375-BRAF<sup>V600E</sup> /NRAS<sup>Q61K</sup> malignant melanoma cells targeting intracranial tumors in a bioluminescent murine model.

Jandova, Jana; Park, Sophia L; Corenblum, Mandi J; Madhavan, Lalitha; Snell, Jeremy A; Rounds, Liliana; Wondrak, Georg T

Mefloquine induces ER stress and apoptosis in BRAFi-resistant A375-BRAF^V600E /NRAS^Q61K malignant melanoma cells targeting intracranial tumors in a bioluminescent murine model.

Jandova, Jana; Park, Sophia L; Corenblum, Mandi J; Madhavan, Lalitha; Snell, Jeremy A; Rounds, Liliana; Wondrak, Georg T.

Afiliación

Jandova J; Department of Pharmacology and Toxicology, RK Coit College of Pharmacy & The University of Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.
Park SL; Department of Pharmacology and Toxicology, RK Coit College of Pharmacy & The University of Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.
Corenblum MJ; Department of Neurology, Evelyn F McKnight Brain Institute and BIO5 Institute, University of Arizona, Tucson, Arizona, USA.
Madhavan L; Department of Neurology, Evelyn F McKnight Brain Institute and BIO5 Institute, University of Arizona, Tucson, Arizona, USA.
Snell JA; Department of Pharmacology and Toxicology, RK Coit College of Pharmacy & The University of Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.
Rounds L; Department of Pharmacology and Toxicology, RK Coit College of Pharmacy & The University of Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.
Wondrak GT; Department of Pharmacology and Toxicology, RK Coit College of Pharmacy & The University of Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.

Mol Carcinog ; 61(6): 603-614, 2022 06.

Article en En | MEDLINE | ID: mdl-35417045

Asunto(s)

Antimaláricos; Neoplasias Encefálicas; Melanoma; Animales; Antimaláricos/farmacología; Antimaláricos/uso terapéutico; Apoptosis; Neoplasias Encefálicas/tratamiento farmacológico; Línea Celular Tumoral; Modelos Animales de Enfermedad; Resistencia a Antineoplásicos/genética; GTP Fosfohidrolasas/genética; Humanos; Mefloquina/farmacología; Mefloquina/uso terapéutico; Melanoma/tratamiento farmacológico; Melanoma/genética; Melanoma/patología; Proteínas de la Membrana/genética; Ratones; Inhibidores de Proteínas Quinasas/farmacología; Proteínas Proto-Oncogénicas B-raf; Neoplasias Cutáneas; Melanoma Cutáneo Maligno

Palabras clave

ER stress; NRAS-driven BRAFi-resistance; antimalarial chemotherapeutics; brain metastases; gene expression array analysis; malignant melanoma; mefloquine

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Melanoma / Antimaláricos Límite: Animals / Humans Idioma: En Revista: Mol Carcinog Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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