Validation of a multiplexed and targeted lipidomics assay for accurate quantification of lipidomes.

Zhang, Nanyan Rena; Hatcher, Nathan G; Ekroos, Kim; Kedia, Komal; Kandebo, Monika; Marcus, Jacob N; Smith, Sean M; Bateman, Kevin P; Spellman, Daniel S

Zhang, Nanyan Rena; Hatcher, Nathan G; Ekroos, Kim; Kedia, Komal; Kandebo, Monika; Marcus, Jacob N; Smith, Sean M; Bateman, Kevin P; Spellman, Daniel S.

Afiliación

Zhang NR; Department of Discovery, Preclinical and Translational Medicine, Merck & Co., Inc., West Point, PA, USA. Electronic address: rena_zhang@merck.com.
Hatcher NG; Department of Neuroscience, Merck & Co., Inc., West Point, PA, USA. Electronic address: Nathan_hatcher@merck.com.
Ekroos K; Lipidomics Consulting Ltd, Esbo, Finland.
Kedia K; Department of Discovery, Preclinical and Translational Medicine, Merck & Co., Inc., West Point, PA, USA.
Kandebo M; Department of Neuroscience, Merck & Co., Inc., West Point, PA, USA.
Marcus JN; Department of Neuroscience, Merck & Co., Inc., West Point, PA, USA.
Smith SM; Department of Neuroscience, Merck & Co., Inc., West Point, PA, USA.
Bateman KP; Department of Discovery, Preclinical and Translational Medicine, Merck & Co., Inc., West Point, PA, USA.
Spellman DS; Department of Discovery, Preclinical and Translational Medicine, Merck & Co., Inc., West Point, PA, USA.

J Lipid Res ; 63(6): 100218, 2022 06.

Article en En | MEDLINE | ID: mdl-35489416

Asunto(s)

Lipidómica; Espectrometría de Masas en Tándem; Animales; Cromatografía Liquida; Lípidos; Ratones; Reproducibilidad de los Resultados; Espectrometría de Masas en Tándem/métodos

Palabras clave

Benzoxazole 1; FDA bioanalytical method validation guidance for industry; glucosylceramide synthase; glycosphingolipid metabolism; hydrophilic interaction chromatography (HILIC); normal phase liquid chromatography (NPLC); quantitative lipidomics; scheduled MRM; targeted lipidomics; triple quadrupole mass spectrometry

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectrometría de Masas en Tándem / Lipidómica Tipo de estudio: Guideline / Prognostic_studies Límite: Animals Idioma: En Revista: J Lipid Res Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos

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