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A responsive fluorescent probe for detecting and imaging pyruvate kinase M2 in live cells.
Zhang, Ya; Li, Huishan; Mai, Hailing; Luo, Dong; Ji, Xinpei; Liu, Zhengting; Peng, Shiyong; Xu, Xuetao; Zhang, Yinghui; Lan, Rongfeng; Li, Hongguang.
Afiliación
  • Zhang Y; Guangdong Provincial Key Laboratory of, Large Animal Models for Biomedicine, School of Biotechnology and Health Science, Wuyi University, Jiangmen 529020, China. wyuchemlihg@126.com.
  • Li H; Guangdong Provincial Key Laboratory of, Large Animal Models for Biomedicine, School of Biotechnology and Health Science, Wuyi University, Jiangmen 529020, China. wyuchemlihg@126.com.
  • Mai H; Guangdong Provincial Key Laboratory of, Large Animal Models for Biomedicine, School of Biotechnology and Health Science, Wuyi University, Jiangmen 529020, China. wyuchemlihg@126.com.
  • Luo D; Guangdong Provincial Key Laboratory of, Large Animal Models for Biomedicine, School of Biotechnology and Health Science, Wuyi University, Jiangmen 529020, China. wyuchemlihg@126.com.
  • Ji X; Guangdong Provincial Key Laboratory of, Large Animal Models for Biomedicine, School of Biotechnology and Health Science, Wuyi University, Jiangmen 529020, China. wyuchemlihg@126.com.
  • Liu Z; Guangdong Provincial Key Laboratory of, Large Animal Models for Biomedicine, School of Biotechnology and Health Science, Wuyi University, Jiangmen 529020, China. wyuchemlihg@126.com.
  • Peng S; Guangdong Provincial Key Laboratory of, Large Animal Models for Biomedicine, School of Biotechnology and Health Science, Wuyi University, Jiangmen 529020, China. wyuchemlihg@126.com.
  • Xu X; Guangdong Provincial Key Laboratory of, Large Animal Models for Biomedicine, School of Biotechnology and Health Science, Wuyi University, Jiangmen 529020, China. wyuchemlihg@126.com.
  • Zhang Y; Guangdong Provincial Key Laboratory of, Large Animal Models for Biomedicine, School of Biotechnology and Health Science, Wuyi University, Jiangmen 529020, China. wyuchemlihg@126.com.
  • Lan R; South China Institute of Large Animal Models for Biomedicine, Wuyi University, Jiangmen 529020, China.
  • Li H; College of Basic medical sciences, Shenzhen University Health Science Center, Shenzhen 518060, China. lan@szu.edu.cn.
Chem Commun (Camb) ; 58(45): 6494-6497, 2022 Jun 01.
Article en En | MEDLINE | ID: mdl-35574810
In this study, we designed and tested fluorescent probe zy-2 for specific and responsive imaging of pyruvate kinase M2 (PKM2), which can be excited by 419 nm light. A 17-fold enhancement in the responsive emission upon zy-2's binding to PKM2 was observed, imaging of which was successfully recorded in a time- and concentration-dependent manner in PKM2-positive cells. Thus, we obtained a responsive fluorescent probe for the specific and sensitive detection of PKM2, which is innovative in design and applicable to the detection of cancer cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piruvato Quinasa / Colorantes Fluorescentes Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piruvato Quinasa / Colorantes Fluorescentes Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido