Activation of Double-Stranded RNA-Activated Protein Kinase in the Dorsal Root Ganglia and Spinal Dorsal Horn Regulates Neuropathic Pain Following Peripheral Nerve Injury in Rats.

Zhang, Jian; Zhang, Xuan; Li, Liren; Bai, Liying; Gao, Yan; Yang, Yin; Wang, Li; Qiao, Yiming; Wang, Xueli; Xu, Ji-Tian

Zhang, Jian; Zhang, Xuan; Li, Liren; Bai, Liying; Gao, Yan; Yang, Yin; Wang, Li; Qiao, Yiming; Wang, Xueli; Xu, Ji-Tian.

Afiliación

Zhang J; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, China.
Zhang X; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, China.
Li L; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, China.
Bai L; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, China.
Gao Y; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital, Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, China.
Yang Y; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, China.
Wang L; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, China.
Qiao Y; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, China.
Wang X; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, China.
Xu JT; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, China.

Neurotherapeutics ; 19(4): 1381-1400, 2022 07.

Article en En | MEDLINE | ID: mdl-35655111

Asunto(s)

Neuralgia; Traumatismos de los Nervios Periféricos; Ratas; Animales; Ganglios Espinales; Traumatismos de los Nervios Periféricos/complicaciones; Traumatismos de los Nervios Periféricos/metabolismo; Interleucina-1beta/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo; ARN Bicatenario/metabolismo; ARN Bicatenario/farmacología; ARN Bicatenario/uso terapéutico; Inhibidor NF-kappaB alfa/metabolismo; FN-kappa B/metabolismo; Interleucina-6/metabolismo; Proteínas Quinasas/metabolismo; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; 2-Aminopurina/metabolismo; 2-Aminopurina/farmacología; 2-Aminopurina/uso terapéutico; Hiperalgesia/metabolismo; Ratas Sprague-Dawley; Neuralgia/tratamiento farmacológico; Asta Dorsal de la Médula Espinal/metabolismo

Palabras clave

Double-stranded RNAactivated kinase; NF-κB; Neuropathic pain; Proinflammatory cytokine; Spinal nerve ligation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de los Nervios Periféricos / Neuralgia Límite: Animals Idioma: En Revista: Neurotherapeutics Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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