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Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1.
Jing, Doudou; Wu, Wei; Chen, Xuanzuo; Xiao, Hongwei; Zhang, Zhenhao; Chen, Fengxia; Zhang, Zhicai; Liu, Jianxiang; Shao, Zengwu; Pu, Feifei.
Afiliación
  • Jing D; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China; Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, PR China. Electronic address: dg142625@163.com.
  • Wu W; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China. Electronic address: waynewu@hust.edu.cn.
  • Chen X; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China. Electronic address: huentso@outlook.com.
  • Xiao H; Key Laboratory of Animal Embryo Engineering and Molecular Breeding of Hubei Province, Institute of Animal Science and Veterinary Medicine, Hubei Academy of Agricultural Sciences, Wuhan, Hubei 430064, PR China. Electronic address: xiaohongwei2003@163.com.
  • Zhang Z; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China. Electronic address: m202075884@hust.edu.cn.
  • Chen F; Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, PR China. Electronic address: fengxiachen@whu.edu.cn.
  • Zhang Z; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China. Electronic address: 2010XH0880@hust.edu.cn.
  • Liu J; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China. Electronic address: liujianxiangljx@163.com.
  • Shao Z; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China. Electronic address: shaozengwupro@163.com.
  • Pu F; Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China. Electronic address: pufeifei@hust.edu.cn.
Pharmacol Res ; 182: 106287, 2022 08.
Article en En | MEDLINE | ID: mdl-35671921
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Óseas / Osteosarcoma Límite: Adolescent / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Óseas / Osteosarcoma Límite: Adolescent / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos