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The first-in-class ERK inhibitor ulixertinib shows promising activity in mitogen-activated protein kinase (MAPK)-driven pediatric low-grade glioma models.
Sigaud, Romain; Rösch, Lisa; Gatzweiler, Charlotte; Benzel, Julia; von Soosten, Laura; Peterziel, Heike; Selt, Florian; Najafi, Sara; Ayhan, Simay; Gerloff, Xenia F; Hofmann, Nina; Büdenbender, Isabel; Schmitt, Lukas; Foerster, Kathrin I; Burhenne, Jürgen; Haefeli, Walter E; Korshunov, Andrey; Sahm, Felix; van Tilburg, Cornelis M; Jones, David T W; Pfister, Stefan M; Knoerzer, Deborah; Kreider, Brent L; Sauter, Max; Pajtler, Kristian W; Zuckermann, Marc; Oehme, Ina; Witt, Olaf; Milde, Till.
Afiliación
  • Sigaud R; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Rösch L; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Gatzweiler C; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Benzel J; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • von Soosten L; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • Peterziel H; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Selt F; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Najafi S; Faculty of Medicine, Heidelberg University, Heidelberg, Germany.
  • Ayhan S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Gerloff XF; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • Hofmann N; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Büdenbender I; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Schmitt L; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • Foerster KI; Preclinical Modeling Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Burhenne J; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Haefeli WE; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Korshunov A; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Sahm F; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • van Tilburg CM; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Jones DTW; KiTZ Clinical Trial Unit, Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.
  • Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Knoerzer D; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Kreider BL; KiTZ Clinical Trial Unit, Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.
  • Sauter M; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Pajtler KW; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Zuckermann M; KiTZ Clinical Trial Unit, Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.
  • Oehme I; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • Witt O; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Milde T; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
Neuro Oncol ; 25(3): 566-579, 2023 03 14.
Article en En | MEDLINE | ID: mdl-35882450
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Quinasas Activadas por Mitógenos / Glioma Límite: Animals Idioma: En Revista: Neuro Oncol Asunto de la revista: NEOPLASIAS / NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Quinasas Activadas por Mitógenos / Glioma Límite: Animals Idioma: En Revista: Neuro Oncol Asunto de la revista: NEOPLASIAS / NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido