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Disease Flare of Systemic Lupus Erythematosus in Patients With Endstage Renal Disease on Dialysis.
Kim, Young-Eun; Choi, Su Jin; Lim, Doo-Ho; Kim, Hyosang; Ahn, Soo Min; Oh, Ji Seon; Kim, Yong-Gil; Lee, Chang-Keun; Yoo, Bin; Hong, Seokchan.
Afiliación
  • Kim YE; Y.E. Kim, MD, S.M. Ahn, MD, Y.G. Kim, MD, PhD, C.K. Lee, MD, PhD, B. Yoo, MD, PhD, and S. Hong, MD, PhD, Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
  • Choi SJ; S.J. Choi, MD, D.H. Lim, MD, PhD, Department of Rheumatology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan.
  • Lim DH; S.J. Choi, MD, D.H. Lim, MD, PhD, Department of Rheumatology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan.
  • Kim H; H. Kim, MD, PhD, Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
  • Ahn SM; Y.E. Kim, MD, S.M. Ahn, MD, Y.G. Kim, MD, PhD, C.K. Lee, MD, PhD, B. Yoo, MD, PhD, and S. Hong, MD, PhD, Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
  • Oh JS; J.S. Oh, MD, PhD, Information Medicine, Big Data Research Center, Asan Medical Center, Seoul, Republic of Korea.
  • Kim YG; Y.E. Kim, MD, S.M. Ahn, MD, Y.G. Kim, MD, PhD, C.K. Lee, MD, PhD, B. Yoo, MD, PhD, and S. Hong, MD, PhD, Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
  • Lee CK; Y.E. Kim, MD, S.M. Ahn, MD, Y.G. Kim, MD, PhD, C.K. Lee, MD, PhD, B. Yoo, MD, PhD, and S. Hong, MD, PhD, Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
  • Yoo B; Y.E. Kim, MD, S.M. Ahn, MD, Y.G. Kim, MD, PhD, C.K. Lee, MD, PhD, B. Yoo, MD, PhD, and S. Hong, MD, PhD, Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul.
  • Hong S; Y.E. Kim, MD, S.M. Ahn, MD, Y.G. Kim, MD, PhD, C.K. Lee, MD, PhD, B. Yoo, MD, PhD, and S. Hong, MD, PhD, Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul; medivineluke@gmail.com.
J Rheumatol ; 49(10): 1131-1137, 2022 Oct.
Article en En | MEDLINE | ID: mdl-35970534
ABSTRACT

OBJECTIVE:

Although systemic lupus erythematosus (SLE) disease activity diminishes after starting dialysis, flares have been documented during dialysis. Hence, we studied the various clinical and therapeutic variables of patients with SLE who had a disease flare while on dialysis.

METHODS:

The medical records of patients with SLE who received dialysis at 2 tertiary referral hospitals in South Korea were reviewed. The disease activity was analyzed in terms of the nonrenal SLE Disease Activity Index (SLEDAI), and the factors associated with SLE flares were evaluated.

RESULTS:

Of the total of 121 patients with SLE on dialysis, 96 (79.3%) were on hemodialysis (HD) and 25 (20.7%) were on peritoneal dialysis (PD). During a median follow-up of 45 months (IQR 23-120) after the initiation of dialysis, 32 (26.4%) patients experienced an SLE flare (HD, n = 25; PD, n = 7). The most common features of SLE flare were hematologic (40.6%; thrombocytopenia [31.2%] and leukopenia [21.8%]) and constitutional manifestations (40.6%). Fever was the most common (34.3%) feature among the constitutional symptoms. Treatments for disease flares were based on corticosteroids, and 11 (34.3%) patients required additional immunosuppressants, including cyclophosphamide and mycophenolate mofetil. Nonrenal SLEDAI score before dialysis initiation (HR 1.24, 95% CI 1.12-1.36; P = 0.001) was a significant risk factor for disease flare during dialysis.

CONCLUSION:

More than a quarter of the patients with SLE experienced a disease flare during dialysis, which most commonly had hematologic manifestations, particularly thrombocytopenia. Continued follow-up and appropriate treatments, including immunosuppressants, should be considered for patients with SLE receiving dialysis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombocitopenia / Fallo Renal Crónico / Lupus Eritematoso Sistémico Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Rheumatol Año: 2022 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombocitopenia / Fallo Renal Crónico / Lupus Eritematoso Sistémico Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Rheumatol Año: 2022 Tipo del documento: Article