Induced expression of CCL19 promotes the anti-tumor ability of CAR-T cells by increasing their infiltration ability.

Hu, Jian-Fei; Wang, Zu-Wei; Liao, Cheng-Yu; Chen, Zhi-Wen; Kang, Feng-Ping; Lin, Cai-Feng; Lin, Tian-Sheng; Huang, Long; Tian, Yi-Feng; Chen, Shi

Hu, Jian-Fei; Wang, Zu-Wei; Liao, Cheng-Yu; Chen, Zhi-Wen; Kang, Feng-Ping; Lin, Cai-Feng; Lin, Tian-Sheng; Huang, Long; Tian, Yi-Feng; Chen, Shi.

Afiliación

Hu JF; Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Wang ZW; Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Liao CY; Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Chen ZW; Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Kang FP; Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Lin CF; Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Lin TS; Department of Hepatopancreatobiliary Surgery, Fujian Provincial Hospital, Fuzhou, China.
Huang L; Department of Hepatopancreatobiliary Surgery, Fujian Provincial Hospital, Fuzhou, China.
Tian YF; Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, China.
Chen S; Department of Hepatopancreatobiliary Surgery, Fujian Provincial Hospital, Fuzhou, China.

Front Immunol ; 13: 958960, 2022.

Article en En | MEDLINE | ID: mdl-35990619

Asunto(s)

Carcinoma Ductal Pancreático; Quimiocina CCL19; Inmunoterapia Adoptiva; Neoplasias Pancreáticas; Receptores Quiméricos de Antígenos; Linfocitos T; Carcinoma Ductal Pancreático/genética; Carcinoma Ductal Pancreático/inmunología; Carcinoma Ductal Pancreático/terapia; Línea Celular Tumoral; Quimiocina CCL19/genética; Quimiocina CCL19/metabolismo; Proteínas Ligadas a GPI/metabolismo; Humanos; Mesotelina; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/inmunología; Neoplasias Pancreáticas/terapia; Neoplasias Pancreáticas

Palabras clave

chemokine (C-C motif) ligand 19 (CCL19); chimeric antigen receptor-engineered T cell (CAR-T); mesothelin; nuclear factor of the activated T cell (NFAT); pancreatic ductal adenocarcinoma

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Linfocitos T / Inmunoterapia Adoptiva / Carcinoma Ductal Pancreático / Quimiocina CCL19 / Receptores Quiméricos de Antígenos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Front Immunol Año: 2022 Tipo del documento: Article País de afiliación: China

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