Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy.

Fan, Hui; Cui, Jiajia; Liu, Feixue; Zhang, Wei; Yang, Haitao; He, Nana; Dong, Zibo; Dong, Jingquan

Fan, Hui; Cui, Jiajia; Liu, Feixue; Zhang, Wei; Yang, Haitao; He, Nana; Dong, Zibo; Dong, Jingquan.

Afiliación

Fan H; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang, 222005, China.
Cui J; Department of Rheumatology and Immunology, The Second People's Hospital of Lianyungang City, Lianyungang, 222000, China.
Liu F; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang, 222005, China.
Zhang W; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang, 222005, China.
Yang H; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang, 222005, China.
He N; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang, 222005, China.
Dong Z; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address: dongzibo999@163.com.
Dong J; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address: 2018000029@jou.edu.cn.

Eur J Pharmacol ; 933: 175252, 2022 Oct 15.

Article en En | MEDLINE | ID: mdl-36063870

Asunto(s)

Enfermedad Hepática Inducida por Sustancias y Drogas; Lipopolisacáridos; Animales; Antocianinas; Antioxidantes/farmacología; Antioxidantes/uso terapéutico; Apoptosis; Autofagia; Catalasa; Enfermedad Hepática Inducida por Sustancias y Drogas/prevención & control; Citocinas/metabolismo; Glutatión Peroxidasa; Inflamasomas/metabolismo; Interleucina-6; Masculino; Ratones; Factor 2 Relacionado con NF-E2/genética; Factor 2 Relacionado con NF-E2/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Proteínas NLR; Sustancias Protectoras/farmacología; ARN Mensajero; Superóxido Dismutasa; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Apoptosis; Autophagy; Hepatotoxicity; Malvidin; NLRP3 inflammasome; Nrf2

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lipopolisacáridos / Enfermedad Hepática Inducida por Sustancias y Drogas Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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