Proline/Glycine residues of the PG-levels guide conformational changes along the transport cycle in the mitochondrial carnitine/acylcarnitine carrier (SLC25A20).

Giangregorio, Nicola; Pierri, Ciro Leonardo; Tonazzi, Annamaria; Incampo, Giovanna; Tragni, Vincenzo; De Grassi, Anna; Indiveri, Cesare

Giangregorio, Nicola; Pierri, Ciro Leonardo; Tonazzi, Annamaria; Incampo, Giovanna; Tragni, Vincenzo; De Grassi, Anna; Indiveri, Cesare.

Afiliación

Giangregorio N; CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), Via Amendola 122/O, 70126 Bari, Italy. Electronic address: n.giangregorio@ibiom.cnr.it.
Pierri CL; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy, Via E. Orabona, 4, 70126 Bari, Italy. Electronic address: ciro.pierri@uniba.it.
Tonazzi A; CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), Via Amendola 122/O, 70126 Bari, Italy.
Incampo G; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy, Via E. Orabona, 4, 70126 Bari, Italy.
Tragni V; CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), Via Amendola 122/O, 70126 Bari, Italy; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy, Via E. Orabona, 4, 70126 Bari, Italy.
De Grassi A; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Italy, Via E. Orabona, 4, 70126 Bari, Italy.
Indiveri C; CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), Via Amendola 122/O, 70126 Bari, Italy; Department DiBEST (Biologia, Ecologia, Scienze della Terra) Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via Bucci 4C, 87036 Arcavacata di Rende, It

Int J Biol Macromol ; 221: 1453-1465, 2022 Nov 30.

Article en En | MEDLINE | ID: mdl-36122779

Asunto(s)

Carnitina Aciltransferasas; Prolina; Carnitina Aciltransferasas/genética; Carnitina Aciltransferasas/química; Carnitina Aciltransferasas/metabolismo; Glicina; Carnitina; Alanina

Palabras clave

Bacterial expression; C-conformation; C-state; Carnitine/acylcarnitine carrier; Conformational changes; Intermediate state; M-conformation; M-state; Mitochondrial carriers; PG-levels; Proline and glycine residues; Proteoliposomes reconstitution; Site-directed mutagenesis; Transport cycle; Transport proteins

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prolina / Carnitina Aciltransferasas Idioma: En Revista: Int J Biol Macromol Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos

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