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Visible-Light-Promoted bis(Difluoromethylation)/Cyclization of 2-Vinyloxy Arylalkynes to Prepare Benzofuran Derivatives.
Wang, Huan; Huang, Yao; Wu, Qiaoyan; Lu, Jun; Xu, Yan-Li; Chen, Yan-Yan.
Afiliación
  • Wang H; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, College of Pharmacy, Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541004, People's Republic of China.
  • Huang Y; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, College of Pharmacy, Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541004, People's Republic of China.
  • Wu Q; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, College of Pharmacy, Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541004, People's Republic of China.
  • Lu J; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, College of Pharmacy, Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541004, People's Republic of China.
  • Xu YL; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, College of Pharmacy, Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541004, People's Republic of China.
  • Chen YY; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, College of Pharmacy, Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541004, People's Republic of China.
J Org Chem ; 87(19): 13288-13299, 2022 10 07.
Article en En | MEDLINE | ID: mdl-36166821
A visible-light-promoted difluoromethylation/cyclization of 2-vinyloxy arylalkynes was developed, providing a variety of bis(difluoromethyl)-substituted benzofurans in moderate to good yields. A plausible mechanism involving difluoromethyl radical cascade cyclization and solvent-promoted ionic addition was proposed. This protocol has the advantages of having mild reaction conditions, simple operation, and good functional group tolerance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzofuranos Idioma: En Revista: J Org Chem Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzofuranos Idioma: En Revista: J Org Chem Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos