Selective oxidative ß-C-H bond sulfenylation of tetrahydroisoquinolines with elemental sulfur.
Org Biomol Chem
; 21(1): 127-131, 2022 12 21.
Article
en En
| MEDLINE
| ID: mdl-36484417
In this article, a convenient and efficient KIO3-promoted oxidative sulfenylation at the ß-position of tetrahydroisoquinolines and subsequent aromatization in the presence of elemental S8 is presented. The reaction proceeds with moderate to good yields via a double C-S formation process. A wide range of structurally diverse 4-sulfenylisoquinolines/3-sulfenylpiperidine were synthesized with excellent functional group tolerance and high efficiency.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tetrahidroisoquinolinas
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2022
Tipo del documento:
Article
Pais de publicación:
Reino Unido