In vitro study to identify ligand-independent function of estrogen receptor-&#945; in suppressing DNA damage-induced chondrocyte senescence.

Zhang, Xiurui; Xiang, Shiqi; Zhang, Yiqian; Liu, Silvia; Lei, Guanghua; Hines, Sophie; Wang, Ning; Lin, Hang

In vitro study to identify ligand-independent function of estrogen receptor-α in suppressing DNA damage-induced chondrocyte senescence.

Zhang, Xiurui; Xiang, Shiqi; Zhang, Yiqian; Liu, Silvia; Lei, Guanghua; Hines, Sophie; Wang, Ning; Lin, Hang.

Afiliación

Zhang X; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Xiang S; Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhang Y; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Liu S; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Lei G; Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hines S; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Wang N; Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lin H; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

FASEB J ; 37(2): e22746, 2023 02.

Article en En | MEDLINE | ID: mdl-36622202

Asunto(s)

Condrocitos; Osteoartritis; Masculino; Humanos; Femenino; Ratones; Animales; Condrocitos/metabolismo; FN-kappa B/metabolismo; Receptores de Estrógenos/metabolismo; Receptor alfa de Estrógeno/genética; Receptor alfa de Estrógeno/metabolismo; Ligandos; Osteoartritis/metabolismo; Senescencia Celular/fisiología; Daño del ADN

Palabras clave

DNA damage; NF-κB pathway; chondrocyte senescence; estrogen receptor-α; osteoarthritis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoartritis / Condrocitos Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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