Allosteric modulation of exosite 1 attenuates polyphosphate-catalyzed activation of factor XI by thrombin.

Yin, Ruiqi; Patel, Vishal; Malik, Rida A; Fredenburgh, James C; Weitz, Jeffrey I

Yin, Ruiqi; Patel, Vishal; Malik, Rida A; Fredenburgh, James C; Weitz, Jeffrey I.

Afiliación

Yin R; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada.
Patel V; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada.
Malik RA; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada.
Fredenburgh JC; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Weitz JI; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada; Department of Medical Sciences, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Biochemistry and Biomedical Sciences, McMaster Universit

J Thromb Haemost ; 21(1): 83-93, 2023 01.

Article en En | MEDLINE | ID: mdl-36695400

Asunto(s)

Factor XI; Trombina; Humanos; Factor XI/metabolismo; Trombina/metabolismo; Polifosfatos/química; Dominio Catalítico; Catálisis

Palabras clave

coagulation; factor XI; polyphosphate; thrombin; thrombosis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor XI / Trombina Límite: Humans Idioma: En Revista: J Thromb Haemost Asunto de la revista: HEMATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Canadá

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