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Discovery and pharmacological characterization of a novel benzimidazole TRPV4 antagonist with cyanocyclobutyl moiety.
Ai, Chongyi; Wang, Zhuang; Li, Pengyun; Wang, Mengyuan; Zhang, Wenjuan; Song, Huijuan; Cai, Xu; Lv, Kai; Chen, Xingjuan; Zheng, Zhibing.
Afiliación
  • Ai C; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; Tianjin Institute of Environmental and Operational Medicine, Tianjin, 300050, China.
  • Wang Z; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710072, China.
  • Li P; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
  • Wang M; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710072, China.
  • Zhang W; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
  • Song H; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • Cai X; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
  • Lv K; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: lvkai@imb.pumc.edu.cn.
  • Chen X; Institute of Medical Research, Northwestern Polytechnical University, Xi'an, 710072, China. Electronic address: xjchen@nwpu.edu.cn.
  • Zheng Z; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China. Electronic address: zzbcaptain@aliyun.com.
Eur J Med Chem ; 249: 115137, 2023 Mar 05.
Article en En | MEDLINE | ID: mdl-36696767
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edema Pulmonar / Canales Catiónicos TRPV Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Edema Pulmonar / Canales Catiónicos TRPV Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia