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Oxytocin receptor is not required for social attachment in prairie voles.
Berendzen, Kristen M; Sharma, Ruchira; Mandujano, Maricruz Alvarado; Wei, Yichao; Rogers, Forrest D; Simmons, Trenton C; Seelke, Adele M H; Bond, Jessica M; Larios, Rose; Goodwin, Nastacia L; Sherman, Michael; Parthasarthy, Srinivas; Espineda, Isidero; Knoedler, Joseph R; Beery, Annaliese; Bales, Karen L; Shah, Nirao M; Manoli, Devanand S.
Afiliación
  • Berendzen KM; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Fra
  • Sharma R; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Fra
  • Mandujano MA; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Wei Y; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Rogers FD; Department of Psychology, University of California, Davis, Davis, CA, USA.
  • Simmons TC; Department of Psychology, University of California, Davis, Davis, CA, USA.
  • Seelke AMH; Department of Psychology, University of California, Davis, Davis, CA, USA.
  • Bond JM; Department of Psychology, University of California, Davis, Davis, CA, USA.
  • Larios R; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Fra
  • Goodwin NL; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Fra
  • Sherman M; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Fra
  • Parthasarthy S; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Espineda I; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
  • Knoedler JR; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
  • Beery A; Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
  • Bales KL; Department of Psychology, University of California, Davis, Davis, CA, USA; Department of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, CA 95616, USA.
  • Shah NM; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA. Electronic address: nirao@stanford.edu.
  • Manoli DS; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Fra
Neuron ; 111(6): 787-796.e4, 2023 03 15.
Article en En | MEDLINE | ID: mdl-36708707
Prairie voles are among a small group of mammals that display long-term social attachment between mating partners. Many pharmacological studies show that signaling via the oxytocin receptor (Oxtr) is critical for the display of social monogamy in these animals. We used CRISPR mutagenesis to generate three different Oxtr-null mutant prairie vole lines. Oxtr mutants displayed social attachment such that males and females showed a behavioral preference for their mating partners over a stranger of the opposite sex, even when assayed using different experimental setups. Mothers lacking Oxtr delivered viable pups, and parents displayed care for their young and raised them to the weanling stage. Together, our studies unexpectedly reveal that social attachment, parturition, and parental behavior can occur in the absence of Oxtr signaling in prairie voles.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Oxitocina / Pradera Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Oxitocina / Pradera Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos