Combining ß-Carotene with 5-FU via Polymeric Nanoparticles as a Novel Therapeutic Strategy to Overcome uL3-Mediated Chemoresistance in p53-Deleted Colorectal Cancer Cells.

Carotenuto, Pietro; Pecoraro, Annalisa; Brignola, Chiara; Barbato, Anna; Franco, Brunella; Longobardi, Giuseppe; Conte, Claudia; Quaglia, Fabiana; Russo, Giulia; Russo, Annapina

Carotenuto, Pietro; Pecoraro, Annalisa; Brignola, Chiara; Barbato, Anna; Franco, Brunella; Longobardi, Giuseppe; Conte, Claudia; Quaglia, Fabiana; Russo, Giulia; Russo, Annapina.

Afiliación

Carotenuto P; TIGEM, Telethon Institute of Genetics and Medicine, 80078 Naples, Italy.
Pecoraro A; Medical Genetics, Department of Translational Medical Science, University of Naples "Federico II", 80131 Naples, Italy.
Brignola C; Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.
Barbato A; Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.
Franco B; TIGEM, Telethon Institute of Genetics and Medicine, 80078 Naples, Italy.
Longobardi G; TIGEM, Telethon Institute of Genetics and Medicine, 80078 Naples, Italy.
Conte C; Medical Genetics, Department of Translational Medical Science, University of Naples "Federico II", 80131 Naples, Italy.
Quaglia F; Scuola Superiore Meridionale, School for Advanced Studies, 80138 Naples, Italy.
Russo G; Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.
Russo A; Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.

Mol Pharm ; 20(5): 2326-2340, 2023 05 01.

Article en En | MEDLINE | ID: mdl-36976623

Asunto(s)

Neoplasias Colorrectales; beta Caroteno; Humanos; beta Caroteno/farmacología; beta Caroteno/metabolismo; beta Caroteno/uso terapéutico; Proteína p53 Supresora de Tumor/genética; Resistencia a Antineoplásicos/genética; Línea Celular Tumoral; Fluorouracilo/farmacología; Fluorouracilo/uso terapéutico; Apoptosis; Neoplasias Colorrectales/tratamiento farmacológico; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/metabolismo; Regulación Neoplásica de la Expresión Génica

Palabras clave

chemoresistance; colorectal cancer; nanoparticles; ribosomal protein uL3; ß-carotene

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Beta Caroteno Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Italia

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