Matrine alleviates oxidative stress and ferroptosis in severe acute pancreatitis-induced acute lung injury by activating the UCP2/SIRT3/PGC1&#945; pathway.

Jin, Hongzhong; Zhao, Kailiang; Li, Juanjuan; Xu, Zhiliang; Liao, Shichong; Sun, Shengrong

Matrine alleviates oxidative stress and ferroptosis in severe acute pancreatitis-induced acute lung injury by activating the UCP2/SIRT3/PGC1α pathway.

Jin, Hongzhong; Zhao, Kailiang; Li, Juanjuan; Xu, Zhiliang; Liao, Shichong; Sun, Shengrong.

Afiliación

Jin H; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, 238 Ziyang Road, Wuhan, Hubei 430060, China; Central Laboratory, Renmin Hospital of Wuhan University, 9 Zhangzhidong Road, Wuhan, Hubei 430060, China.
Zhao K; Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei 430060, China.
Li J; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, 238 Ziyang Road, Wuhan, Hubei 430060, China.
Xu Z; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, 238 Ziyang Road, Wuhan, Hubei 430060, China.
Liao S; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, 238 Ziyang Road, Wuhan, Hubei 430060, China. Electronic address: liaoscwhu@163.com.
Sun S; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, 238 Ziyang Road, Wuhan, Hubei 430060, China. Electronic address: sun137@sina.com.

Int Immunopharmacol ; 117: 109981, 2023 Apr.

Article en En | MEDLINE | ID: mdl-37012871

Asunto(s)

Lesión Pulmonar Aguda; Ferroptosis; Pancreatitis; Sirtuina 3; Ratones; Animales; Pancreatitis/complicaciones; Especies Reactivas de Oxígeno/metabolismo; Matrinas; Sirtuina 3/genética; Sirtuina 3/metabolismo; Lipopolisacáridos/farmacología; Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma/genética; Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma/metabolismo; Enfermedad Aguda; Estrés Oxidativo; Inflamación/patología; Lesión Pulmonar Aguda/inducido químicamente; Antioxidantes/farmacología; Ratones Endogámicos C57BL

Palabras clave

Acute lung injury; Acute pancreatitis; Ferroptosis; Matrine; Oxidative stress; UCP2

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pancreatitis / Lesión Pulmonar Aguda / Sirtuina 3 / Ferroptosis Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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