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Dual truncation of tau by caspase-2 accelerates its CHIP-mediated degradation.
Reinhardt, Lydia; Musacchio, Fabrizio; Bichmann, Maria; Behrendt, Annika; Ercan-Herbst, Ebru; Stein, Juliane; Becher, Isabelle; Haberkant, Per; Mader, Julia; Schöndorf, David C; Schmitt, Melanie; Korffmann, Jürgen; Reinhardt, Peter; Pohl, Christian; Savitski, Mikhail; Klein, Corinna; Gasparini, Laura; Fuhrmann, Martin; Ehrnhoefer, Dagmar E.
Afiliación
  • Reinhardt L; BioMed X Institute, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen am Rhein, Germany.
  • Musacchio F; Neuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Building 99, 53127 Bonn, Germany.
  • Bichmann M; BioMed X Institute, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany.
  • Behrendt A; BioMed X Institute, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany.
  • Ercan-Herbst E; BioMed X Institute, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany.
  • Stein J; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen am Rhein, Germany.
  • Becher I; European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, 69117 Heidelberg, Germany.
  • Haberkant P; European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, 69117 Heidelberg, Germany.
  • Mader J; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen am Rhein, Germany.
  • Schöndorf DC; BioMed X Institute, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen am Rhein, Germany.
  • Schmitt M; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen am Rhein, Germany.
  • Korffmann J; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen am Rhein, Germany.
  • Reinhardt P; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen am Rhein, Germany.
  • Pohl C; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen am Rhein, Germany.
  • Savitski M; European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, 69117 Heidelberg, Germany.
  • Klein C; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen am Rhein, Germany.
  • Gasparini L; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen am Rhein, Germany.
  • Fuhrmann M; Neuroimmunology and Imaging Group, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1, Building 99, 53127 Bonn, Germany.
  • Ehrnhoefer DE; BioMed X Institute, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany; AbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery, Knollstrasse, 67061 Ludwigshafen am Rhein, Germany. Electronic address: dagmar.ehrnhoefer@abbvie.com.
Neurobiol Dis ; 182: 106126, 2023 06 15.
Article en En | MEDLINE | ID: mdl-37086756
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas tau / Caspasa 2 Límite: Animals / Female / Humans / Male Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas tau / Caspasa 2 Límite: Animals / Female / Humans / Male Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos