Synthesised thymoquinone-oxime induces cytotoxicity, genotoxicity and apoptosis in hepatocellular cancer cells: <i>in vitro</i> study.

Guler, Eray Metin; Bozali, Kubra

Synthesised thymoquinone-oxime induces cytotoxicity, genotoxicity and apoptosis in hepatocellular cancer cells: in vitro study.

Guler, Eray Metin; Bozali, Kubra.

Afiliación

Guler EM; Department of Medical Biochemistry, University of Health Sciences Turkey, Hamidiye School of Medicine, Istanbul, Turkey.
Bozali K; Haydarpasa Numune Health Application and Research Center, Department of Medical Biochemistry, University of Health Sciences Turkey, Istanbul, Turkey.

Nat Prod Res ; 38(10): 1695-1703, 2024 May.

Article en En | MEDLINE | ID: mdl-37254835

Among many herbs, Black seed (Nigella sativa) belonging to the Ranunculaceae family has been recognised worldwide as one of the most valuable nutrient-rich herbsThere is no relevant data on the effect of the newly synthesised oxime derivative of TQ (TQ-ox) in cancer cells HEP-G2A new TQ derivative has a higher anti-tumor effect on hepatocellular carcinoma.

Asunto(s)

Carcinoma Hepatocelular; Neoplasias Hepáticas; Humanos; Especies Reactivas de Oxígeno/metabolismo; Calcio; Línea Celular Tumoral; Apoptosis; Benzoquinonas/química; Daño del ADN

Palabras clave

Hepatocellular carcinoma; oxime; thymoquinone; thymoquinone-oxime

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Nat Prod Res Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido

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