Action of histamine on PHA chemiluminescence response of blood mononuclear cells in autoimmune patients.
Agents Actions
; 18(1-2): 254-7, 1986 Apr.
Article
en En
| MEDLINE
| ID: mdl-3728210
ABSTRACT
Peripheral blood mononuclear cells (PBMs) of patients suffering from autoimmune diseases showed significantly lower chemiluminescence response to PHA than the controls. High doses of histamine (10(-5) M) inhibited the chemiluminescence while low doses caused a mild enhancement in all groups of patients. The preformed histamine content of the PBMs was not significantly higher in the patients than in the controls. Individually, a reverse correlation was found between the activity of the disease and the sensitivity of the cells to histamine. In very active cases, virtually no inhibition by histamine was found.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fitohemaglutininas
/
Enfermedades Autoinmunes
/
Linfocitos
/
Monocitos
/
Histamina
Límite:
Humans
Idioma:
En
Revista:
Agents Actions
Año:
1986
Tipo del documento:
Article