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Integrating genetics and metabolomics from multi-ethnic and multi-fluid data reveals putative mechanisms for age-related macular degeneration.
Han, Xikun; Lains, Ines; Li, Jun; Li, Jinglun; Chen, Yiheng; Yu, Bing; Qi, Qibin; Boerwinkle, Eric; Kaplan, Robert; Thyagarajan, Bharat; Daviglus, Martha; Joslin, Charlotte E; Cai, Jianwen; Guasch-Ferré, Marta; Tobias, Deirdre K; Rimm, Eric; Ascherio, Alberto; Costenbader, Karen; Karlson, Elizabeth; Mucci, Lorelei; Eliassen, A Heather; Zeleznik, Oana; Miller, John; Vavvas, Demetrios G; Kim, Ivana K; Silva, Rufino; Miller, Joan; Hu, Frank; Willett, Walter; Lasky-Su, Jessica; Kraft, Peter; Richards, J Brent; MacGregor, Stuart; Husain, Deeba; Liang, Liming.
Afiliación
  • Han X; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: xikun_han@hsph.harvard.edu.
  • Lains I; Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
  • Li J; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Li J; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Chen Y; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, QC, Canada; Department of Human Genetics, McGill University, Montréal, QC, Canada.
  • Yu B; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Qi Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Boerwinkle E; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Thyagarajan B; Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Minneapolis, MN, USA.
  • Daviglus M; Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA.
  • Joslin CE; Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
  • Cai J; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Guasch-Ferré M; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Tobias DK; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Rimm E; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Ascherio A; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Costenbader K; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Karlson E; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Mucci L; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Eliassen AH; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston,
  • Zeleznik O; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Miller J; Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
  • Vavvas DG; Retina Service, Ines and Fredrick Yeatts Retinal Research Laboratory, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
  • Kim IK; Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
  • Silva R; Ophthalmology Unit, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal; University Clinic of Ophthalmology, Faculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal; Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal.
  • Miller J; Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
  • Hu F; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Willett W; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Lasky-Su J; Systems Genetics and Genomics Unit, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
  • Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Richards JB; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, QC, Canada; Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal, QC, Canada; Department of Twin Research, King's College London, London, UK; Five Prime Sciences Inc, Montréal,
  • MacGregor S; Statistical Genetics Lab, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia.
  • Husain D; Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. Electronic address: deeba_husain@meei.harvard.edu.
  • Liang L; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Elect
Cell Rep Med ; 4(7): 101085, 2023 07 18.
Article en En | MEDLINE | ID: mdl-37348500
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo / Degeneración Macular Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: Cell Rep Med Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo / Degeneración Macular Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: Cell Rep Med Año: 2023 Tipo del documento: Article Pais de publicación: Estados Unidos