[Correction of the pathogenic mutation in the G6PC3 gene by adenine base editing in mutant embryos].

Hong, M; Wang, P; Shangguan, T; Li, G L; Bian, R P; He, W; Jiang, W; Chen, J P

Hong, M; Wang, P; Shangguan, T; Li, G L; Bian, R P; He, W; Jiang, W; Chen, J P.

Afiliación

Hong M; Guizhou University Medical College, Guiyang 550025, China.
Wang P; Department of Hematology, the First Affiliated Hospital of Army Medical University (Southwest Hospital), Chongqing 400038, China.
Shangguan T; Department of Reproductive Medicine, the First Affiliated Hospital of Army Medical University (Southwest Hospital), Chongqing 400038, China.
Li GL; Department of Reproductive Medicine, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
Bian RP; Guizhou University Medical College, Guiyang 550025, China.
He W; Department of Reproductive Medicine, the First Affiliated Hospital of Army Medical University (Southwest Hospital), Chongqing 400038, China.
Jiang W; Department of Hematology, the First Affiliated Hospital of Army Medical University (Southwest Hospital), Chongqing 400038, China.
Chen JP; Department of Hematology, the First Affiliated Hospital of Army Medical University (Southwest Hospital), Chongqing 400038, China.

Zhonghua Xue Ye Xue Za Zhi ; 44(4): 308-315, 2023 Apr 14.

Article en Zh | MEDLINE | ID: mdl-37357000

Asunto(s)

Sistemas CRISPR-Cas; Edición Génica; Humanos; Adenina; Células HEK293; Mutación; Glucosa-6-Fosfatasa/genética; Glucosa-6-Fosfatasa/metabolismo

Palabras clave

Base editing; Embryo correction; Gene, G6PC3; Severe congenital neutropenia

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas CRISPR-Cas / Edición Génica Límite: Humans Idioma: Zh Revista: Zhonghua Xue Ye Xue Za Zhi Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: China

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