Evaluation of Novel B1R/B2R Agonists Containing TRIOZAN&#8482; Nanoparticles for Targeted Brain Delivery of Antibodies in a Mouse Model of Alzheimer Disease.

Gagnon, Maxime; Savard, Martin; Tran, Thi Minh Hue; Vincent, Laurence; Moquin, Alexandre; Tremblay, Philippe; Roucou, Xavier; Dory, Yves; Gobeil, Fernand

Evaluation of Novel B1R/B2R Agonists Containing TRIOZAN™ Nanoparticles for Targeted Brain Delivery of Antibodies in a Mouse Model of Alzheimer Disease.

Gagnon, Maxime; Savard, Martin; Tran, Thi Minh Hue; Vincent, Laurence; Moquin, Alexandre; Tremblay, Philippe; Roucou, Xavier; Dory, Yves; Gobeil, Fernand.

Afiliación

Gagnon M; Department of Pharmacology & Physiology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Savard M; Department of Pharmacology & Physiology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Tran TMH; Department of Chemistry, Université de Sherbrooke, Sherbrooke, QC J1R 2R1, Canada.
Vincent L; Department of Pharmacology & Physiology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Moquin A; Ovensa Innovations Inc., 101 Boulevard Cartier Ouest, Laval, QC H7Y 5B7, Canada.
Tremblay P; Ovensa Innovations Inc., 101 Boulevard Cartier Ouest, Laval, QC H7Y 5B7, Canada.
Roucou X; Department of Biochemistry & Functional Genomics, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Dory Y; Department of Chemistry, Université de Sherbrooke, Sherbrooke, QC J1R 2R1, Canada.
Gobeil F; Department of Pharmacology & Physiology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.

Molecules ; 28(13)2023 Jul 04.

Article en En | MEDLINE | ID: mdl-37446867

Asunto(s)

Enfermedad de Alzheimer; Animales; Ratones; Enfermedad de Alzheimer/tratamiento farmacológico; Enfermedad de Alzheimer/metabolismo; Distribución Tisular; Receptor de Bradiquinina B2/agonistas; Receptor de Bradiquinina B2/metabolismo; Receptor de Bradiquinina B1/agonistas; Receptor de Bradiquinina B1/metabolismo; Encéfalo/metabolismo; Modelos Animales de Enfermedad

Palabras clave

Alzheimer disease; B1 and B2 receptors; biologics; bloodbrain barrier; kinin agonist analogues; nanoformulations

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza

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