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MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas.
Sigaud, Romain; Albert, Thomas K; Hess, Caroline; Hielscher, Thomas; Winkler, Nadine; Kocher, Daniela; Walter, Carolin; Münter, Daniel; Selt, Florian; Usta, Diren; Ecker, Jonas; Brentrup, Angela; Hasselblatt, Martin; Thomas, Christian; Varghese, Julian; Capper, David; Thomale, Ulrich W; Hernáiz Driever, Pablo; Simon, Michèle; Horn, Svea; Herz, Nina Annika; Koch, Arend; Sahm, Felix; Hamelmann, Stefan; Faria-Andrade, Augusto; Jabado, Nada; Schuhmann, Martin U; Schouten-van Meeteren, Antoinette Y N; Hoving, Eelco; Brummer, Tilman; van Tilburg, Cornelis M; Pfister, Stefan M; Witt, Olaf; Jones, David T W; Kerl, Kornelius; Milde, Till.
Afiliación
  • Sigaud R; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. r.sigaud@kitz-heidelberg.de.
  • Albert TK; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany. r.sigaud@kitz-heidelberg.de.
  • Hess C; National Center for Tumor Diseases (NCT), Heidelberg, Germany. r.sigaud@kitz-heidelberg.de.
  • Hielscher T; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.
  • Winkler N; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Kocher D; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Walter C; National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  • Münter D; Faculty of Biochemistry, Heidelberg University, Heidelberg, Germany.
  • Selt F; Division of Biostatistics, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Usta D; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Ecker J; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Brentrup A; National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  • Hasselblatt M; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • Thomas C; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Varghese J; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Capper D; National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  • Thomale UW; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • Hernáiz Driever P; Institute of Medical Informatics, University of Münster, Münster, Germany.
  • Simon M; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.
  • Horn S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Herz NA; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Koch A; National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  • Sahm F; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
  • Hamelmann S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Faria-Andrade A; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Jabado N; National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  • Schuhmann MU; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
  • Schouten-van Meeteren AYN; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Hoving E; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
  • Brummer T; National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  • van Tilburg CM; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.
  • Pfister SM; Neurosurgery Dept., University Hospital Münster, Münster, Germany.
  • Witt O; Institute of Neuropathology, University Hospital Münster, Münster, Germany.
  • Jones DTW; Institute of Neuropathology, University Hospital Münster, Münster, Germany.
  • Kerl K; Institute of Medical Informatics, University of Münster, Münster, Germany.
  • Milde T; Berlin Institute of Health, Anna-Louisa-Karsch-Straße 2, 10178, Berlin, Germany.
Nat Commun ; 14(1): 4533, 2023 07 27.
Article en En | MEDLINE | ID: mdl-37500667
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glioma Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glioma Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido