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The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.
Baumgartner, Christina K; Ebrahimi-Nik, Hakimeh; Iracheta-Vellve, Arvin; Hamel, Keith M; Olander, Kira E; Davis, Thomas G R; McGuire, Kathleen A; Halvorsen, Geoff T; Avila, Omar I; Patel, Chirag H; Kim, Sarah Y; Kammula, Ashwin V; Muscato, Audrey J; Halliwill, Kyle; Geda, Prasanthi; Klinge, Kelly L; Xiong, Zhaoming; Duggan, Ryan; Mu, Liang; Yeary, Mitchell D; Patti, James C; Balon, Tyler M; Mathew, Rebecca; Backus, Carey; Kennedy, Domenick E; Chen, Angeline; Longenecker, Kenton; Klahn, Joseph T; Hrusch, Cara L; Krishnan, Navasona; Hutchins, Charles W; Dunning, Jax P; Bulic, Marinka; Tiwari, Payal; Colvin, Kayla J; Chuong, Cun Lan; Kohnle, Ian C; Rees, Matthew G; Boghossian, Andrew; Ronan, Melissa; Roth, Jennifer A; Wu, Meng-Ju; Suermondt, Juliette S M T; Knudsen, Nelson H; Cheruiyot, Collins K; Sen, Debattama R; Griffin, Gabriel K; Golub, Todd R; El-Bardeesy, Nabeel; Decker, Joshua H.
Afiliación
  • Baumgartner CK; AbbVie, North Chicago, IL, USA. christina.baumgartner@abbvie.com.
  • Ebrahimi-Nik H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Iracheta-Vellve A; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Hamel KM; Ohio State University Comprehensive Cancer Center and Pelotonia Institute for Immuno-Oncology, Columbus, OH, USA.
  • Olander KE; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Davis TGR; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • McGuire KA; Pfizer, Groton, CT, USA.
  • Halvorsen GT; AbbVie, North Chicago, IL, USA.
  • Avila OI; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Patel CH; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Kim SY; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kammula AV; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Muscato AJ; AbbVie, North Chicago, IL, USA.
  • Halliwill K; AbbVie, North Chicago, IL, USA.
  • Geda P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Klinge KL; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Xiong Z; Calico Life Sciences, South San Francisco, CA, USA.
  • Duggan R; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Mu L; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Yeary MD; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Patti JC; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Balon TM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Mathew R; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Backus C; AbbVie, South San Francisco, CA, USA.
  • Kennedy DE; AbbVie, North Chicago, IL, USA.
  • Chen A; Bristol Myers Squibb, Summit, NJ, USA.
  • Longenecker K; AbbVie, North Chicago, IL, USA.
  • Klahn JT; AbbVie, North Chicago, IL, USA.
  • Hrusch CL; Ipsen Biosciences, Cambridge, MA, USA.
  • Krishnan N; AbbVie, North Chicago, IL, USA.
  • Hutchins CW; AbbVie, North Chicago, IL, USA.
  • Dunning JP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Bulic M; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Tiwari P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Colvin KJ; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Chuong CL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kohnle IC; Center for Cancer Research and Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Rees MG; AbbVie, South San Francisco, CA, USA.
  • Boghossian A; AbbVie, South San Francisco, CA, USA.
  • Ronan M; AbbVie, North Chicago, IL, USA.
  • Roth JA; AbbVie, North Chicago, IL, USA.
  • Wu MJ; AbbVie, North Chicago, IL, USA.
  • Suermondt JSMT; AbbVie, North Chicago, IL, USA.
  • Knudsen NH; AbbVie, North Chicago, IL, USA.
  • Cheruiyot CK; AbbVie, North Chicago, IL, USA.
  • Sen DR; Monte Rosa Therapeutics, Boston, MA, USA.
  • Griffin GK; AbbVie, North Chicago, IL, USA.
  • Golub TR; AbbVie, North Chicago, IL, USA.
  • El-Bardeesy N; AbbVie, North Chicago, IL, USA.
  • Decker JH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Nature ; 622(7984): 850-862, 2023 Oct.
Article en En | MEDLINE | ID: mdl-37794185
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Tirosina Fosfatasa no Receptora Tipo 1 / Proteína Tirosina Fosfatasa no Receptora Tipo 2 / Inmunoterapia / Neoplasias Límite: Animals / Humans Idioma: En Revista: Nature Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Tirosina Fosfatasa no Receptora Tipo 1 / Proteína Tirosina Fosfatasa no Receptora Tipo 2 / Inmunoterapia / Neoplasias Límite: Animals / Humans Idioma: En Revista: Nature Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido