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Real-World Sensitization and Tolerance Pattern to Seafood in Fish-Allergic Individuals.
Leung, Agnes S Y; Wai, Christine Y Y; Leung, Nicki Y H; Ngai, Noelle Anne; Chua, Gilbert T; Ho, Po Ki; Lam, Ivan C S; Cheng, James W C H; Chan, Oi Man; Li, Pui Fung; Au, Ann W S; Leung, Chloris H W; Cheng, Nam Sze; Tang, Man Fung; Fong, Brian L Y; Rosa Duque, Jaime S; Wong, Joshua S C; Luk, David C K; Ho, Marco H K; Kwan, Mike Y W; Yau, Yat Sun; Lee, Qun Ui; Chan, Wai Hung; Wong, Gary W K; Leung, Ting Fan.
Afiliación
  • Leung ASY; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the Peop
  • Wai CYY; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Leung NYH; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Ngai NA; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Chua GT; Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Ho PK; Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Lam ICS; Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong Special Administrative Region of the People's Republic of China, China; Department of Paediatrics and Adolescent Medicine, Yan Chai Hospital, Hong Kong Special Administrative Region of the People's Republic of C
  • Cheng JWCH; Department of Paediatrics and Adolescent Medicine, United Christian Hospital, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Chan OM; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Li PF; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Au AWS; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Leung CHW; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Cheng NS; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Tang MF; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the Peop
  • Fong BLY; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Rosa Duque JS; Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Wong JSC; Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong Special Administrative Region of the People's Republic of China, China; Department of Paediatrics and Adolescent Medicine, Yan Chai Hospital, Hong Kong Special Administrative Region of the People's Republic of C
  • Luk DCK; Department of Paediatrics and Adolescent Medicine, United Christian Hospital, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Ho MHK; Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, the University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Kwan MYW; Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong Special Administrative Region of the People's Republic of China, China; Department of Paediatrics and Adolescent Medicine, Yan Chai Hospital, Hong Kong Special Administrative Region of the People's Republic of C
  • Yau YS; Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Lee QU; Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong Special Administrative Region of the People's Republic of China, China; Department of Paediatrics and Adolescent Medicine, Yan Chai Hospital, Hong Kong Special Administrative Region of the People's Republic of C
  • Chan WH; Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Wong GWK; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China.
  • Leung TF; Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the People's Republic of China, China; Hong Kong Hub of Paediatric Excellence, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of the Peop
J Allergy Clin Immunol Pract ; 12(3): 633-642.e9, 2024 Mar.
Article en En | MEDLINE | ID: mdl-37802255
BACKGROUND: Seafood is a common cause of food allergy and anaphylaxis, but there are limited published real-world data describing the clinical presentation of fish and shellfish allergies. OBJECTIVE: This study aimed to examine the clinical characteristics, immunological profile, and tolerance pattern to fish, crustaceans, and mollusks in fish-allergic individuals. METHODS: Patients presenting with IgE-mediated fish allergy between 2016 and 2021 were recruited. A comprehensive sensitization profile including specific IgE and skin prick test to various fish and shellfish species and a detailed clinical history including individuals' recent seafood consumption were evaluated. RESULTS: A total of 249 fish-allergic individuals (aged 4.2 ± 5.8 years) were recruited from 6 allergy clinics in Hong Kong, and they had experienced their fish-allergic reaction 2.2 ± 3.4 years before enrollment. Seventy-five subjects (30%) reacted to either grass carp, salmon, grouper, or cod in oral food challenges. We identified an IgE sensitization gradient that corresponded to the level of ß-parvalbumin in fish. In total, 40% of fish-allergic individuals reported tolerance to 1 or more types of fish, more commonly to fish with a lower ß-parvalbumin level such as tuna and salmon, compared with ß-parvalbumin-rich fish such as catfish and grass carp. Despite fish and shellfish cosensitization, 41% of individuals reported tolerance to crustaceans, mollusks, or both, whereas shellfish avoidance occurred in half of the fish-allergic individuals, of whom 33% lacked shellfish sensitization. CONCLUSIONS: Fish allergy commonly presents in early childhood. A considerable proportion of fish-allergic patients are selectively tolerant to certain fish, typically those with lower levels of ß-parvalbumin. There is an unmet need to promote precision medicine for seafood allergies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Parvalbúminas / Hipersensibilidad a los Alimentos Tipo de estudio: Prognostic_studies Límite: Animals / Child, preschool / Humans Idioma: En Revista: J Allergy Clin Immunol Pract Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Parvalbúminas / Hipersensibilidad a los Alimentos Tipo de estudio: Prognostic_studies Límite: Animals / Child, preschool / Humans Idioma: En Revista: J Allergy Clin Immunol Pract Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos