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A protein kinase C α and ß inhibitor blunts hyperphagia to halt renal function decline and reduces adiposity in a rat model of obesity-driven type 2 diabetes.
Wang, Ju; Casimiro-Garcia, Agustin; Johnson, Bryce G; Duffen, Jennifer; Cain, Michael; Savary, Leigh; Wang, Stephen; Nambiar, Prashant; Lech, Matthew; Zhao, Shanrong; Xi, Li; Zhan, Yutian; Olson, Jennifer; Stejskal, James A; Lin, Hank; Zhang, Baohong; Martinez, Robert V; Masek-Hammerman, Katherine; Schlerman, Franklin J; Dower, Ken.
Afiliación
  • Wang J; Inflammation and Immunology, Pfizer Worldwide Research and Development, Cambridge, MA, USA. ju.wang@pfizer.com.
  • Casimiro-Garcia A; Medicine Design, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
  • Johnson BG; Inflammation and Immunology, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
  • Duffen J; Inflammation and Immunology, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
  • Cain M; Inflammation and Immunology, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
  • Savary L; Mediar Therapeutics, Boston, MA, USA.
  • Wang S; Inflammation and Immunology, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
  • Nambiar P; Instem Life Science Systems Ltd, Mount Ida College, South Hadley, MA, USA.
  • Lech M; Pharmacokinetics and Drug Metabolism, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
  • Zhao S; Novartis Gene Therapies, Novartis Institute for Biomedical Research, Cambridge, MA, USA.
  • Xi L; Drug Safety Research and Development, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
  • Zhan Y; Strand Therapeutics, Cambridge, MA, USA.
  • Olson J; Inflammation and Immunology, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
  • Stejskal JA; Clinical Genetics and Bioinformatics, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
  • Lin H; Amunix Pharmaceuticals, San Francisco, CA, USA.
  • Zhang B; Early Clinical Development, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
  • Martinez RV; Drug Safety Research and Development, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
  • Masek-Hammerman K; Drug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT, USA.
  • Schlerman FJ; Drug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT, USA.
  • Dower K; Charles River Laboratories, Shrewsbury, MA, USA.
Sci Rep ; 13(1): 16919, 2023 10 07.
Article en En | MEDLINE | ID: mdl-37805649

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Adiposidad Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Adiposidad Límite: Animals / Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido