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Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target.
Roychowdhury, Tanmoy; Klarin, Derek; Levin, Michael G; Spin, Joshua M; Rhee, Yae Hyun; Deng, Alicia; Headley, Colwyn A; Tsao, Noah L; Gellatly, Corry; Zuber, Verena; Shen, Fred; Hornsby, Whitney E; Laursen, Ina Holst; Verma, Shefali S; Locke, Adam E; Einarsson, Gudmundur; Thorleifsson, Gudmar; Graham, Sarah E; Dikilitas, Ozan; Pattee, Jack W; Judy, Renae L; Pauls-Verges, Ferran; Nielsen, Jonas B; Wolford, Brooke N; Brumpton, Ben M; Dilmé, Jaume; Peypoch, Olga; Juscafresa, Laura Calsina; Edwards, Todd L; Li, Dadong; Banasik, Karina; Brunak, Søren; Jacobsen, Rikke L; Garcia-Barrio, Minerva T; Zhang, Jifeng; Rasmussen, Lars M; Lee, Regent; Handa, Ashok; Wanhainen, Anders; Mani, Kevin; Lindholt, Jes S; Obel, Lasse M; Strauss, Ewa; Oszkinis, Grzegorz; Nelson, Christopher P; Saxby, Katie L; van Herwaarden, Joost A; van der Laan, Sander W; van Setten, Jessica; Camacho, Mercedes.
Afiliación
  • Roychowdhury T; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA. tanmoy63@gmail.com.
  • Klarin D; Department of Genetics, Yale School of Medicine, New Haven, CT, USA. tanmoy63@gmail.com.
  • Levin MG; Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Spin JM; VA Palo Alto Healthcare System, Palo Alto, CA, USA.
  • Rhee YH; Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
  • Deng A; VA Palo Alto Healthcare System, Palo Alto, CA, USA.
  • Headley CA; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Tsao NL; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
  • Gellatly C; VA Palo Alto Healthcare System, Palo Alto, CA, USA.
  • Zuber V; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Shen F; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
  • Hornsby WE; VA Palo Alto Healthcare System, Palo Alto, CA, USA.
  • Laursen IH; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Verma SS; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
  • Locke AE; VA Palo Alto Healthcare System, Palo Alto, CA, USA.
  • Einarsson G; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Thorleifsson G; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
  • Graham SE; Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
  • Dikilitas O; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Pattee JW; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • Judy RL; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Pauls-Verges F; UK Dementia Research Institute at Imperial College, Imperial College London, London, UK.
  • Nielsen JB; University of Michigan Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, USA.
  • Wolford BN; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Brumpton BM; Department of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
  • Dilmé J; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA, USA.
  • Peypoch O; Regeneron Genetics Center, LLC, Tarrytown, NY, USA.
  • Juscafresa LC; deCODE genetics/Amgen Inc., Reykjavik, Iceland.
  • Edwards TL; deCODE genetics/Amgen Inc., Reykjavik, Iceland.
  • Li D; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Banasik K; Department of Internal Medicine, Mayo Clinic Rochester, Rochester, MN, USA.
  • Brunak S; Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic Rochester, Rochester, MN, USA.
  • Jacobsen RL; Mayo Clinician Investigator Training Program, Mayo Clinic Rochester, Rochester, MN, USA.
  • Garcia-Barrio MT; University of Minnesota, Minneapolis, MN, USA.
  • Zhang J; Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
  • Rasmussen LM; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.
  • Lee R; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
  • Handa A; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.
  • Wanhainen A; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
  • Mani K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
  • Lindholt JS; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.
  • Obel LM; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
  • Strauss E; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
  • Oszkinis G; Department of Vascular and Endovascular Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.
  • Nelson CP; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.
  • Saxby KL; Department of Vascular and Endovascular Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.
  • van Herwaarden JA; Vascular Surgery Department, Parc de Salut Mar-Hospital del Mar, Barcelona, Spain.
  • van der Laan SW; Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
  • van Setten J; Regeneron Genetics Center, LLC, Tarrytown, NY, USA.
  • Camacho M; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Nat Genet ; 55(11): 1831-1842, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37845353
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aneurisma de la Aorta Abdominal / Estudio de Asociación del Genoma Completo Tipo de estudio: Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aneurisma de la Aorta Abdominal / Estudio de Asociación del Genoma Completo Tipo de estudio: Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos