Evaluation of Alectinib Metabolic Stability in HLMs Using Fast LC-MS/MS Method: In Silico ADME Profile, P450 Metabolic Lability, and Toxic Alerts Screening.

Attwa, Mohamed W; AlRabiah, Haitham; Mostafa, Gamal A E; Kadi, Adnan A

Attwa, Mohamed W; AlRabiah, Haitham; Mostafa, Gamal A E; Kadi, Adnan A.

Afiliación

Attwa MW; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
AlRabiah H; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Mostafa GAE; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Kadi AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Pharmaceutics ; 15(10)2023 Oct 11.

Article en En | MEDLINE | ID: mdl-37896209

Palabras clave

ADME profile; DEREK software; LC-MS/MS approach; P450 metabolic mode; StarDrop software; alectinib; greenness; in vitro half-life; intrinsic clearance; metabolic stability

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmaceutics Año: 2023 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google