Combined Inhibition of UBE2C and PLK1 Reduce Cell Proliferation and Arrest Cell Cycle by Affecting ACLY in Pan-Cancer.

Liang, Keying; Wang, Qian; Qiu, Li; Gong, Xiaocheng; Chen, Zixi; Zhang, Haibo; Ding, Ke; Liu, Yunfei; Wei, Jinfen; Lin, Shudai; Fu, Shuying; Du, Hongli

Combined Inhibition of UBE2C and PLK1 Reduce Cell Proliferation and Arrest Cell Cycle by Affecting ACLY in Pan-Cancer.

Liang, Keying; Wang, Qian; Qiu, Li; Gong, Xiaocheng; Chen, Zixi; Zhang, Haibo; Ding, Ke; Liu, Yunfei; Wei, Jinfen; Lin, Shudai; Fu, Shuying; Du, Hongli.

Afiliación

Liang K; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Wang Q; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Qiu L; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Gong X; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Chen Z; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Zhang H; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Ding K; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Liu Y; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Wei J; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Lin S; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Fu S; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.
Du H; School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.

Int J Mol Sci ; 24(21)2023 Oct 27.

Article en En | MEDLINE | ID: mdl-37958642

Asunto(s)

Neoplasias; Humanos; Neoplasias/tratamiento farmacológico; Neoplasias/genética; Proliferación Celular; División Celular; Proteínas de Ciclo Celular/genética; Línea Celular Tumoral; Enzimas Ubiquitina-Conjugadoras/genética; Enzimas Ubiquitina-Conjugadoras/metabolismo

Palabras clave

ATP-citrate lyase (ACLY); baculoviral IAP repeat containing 5 (BIRC5); cell cycle; cell proliferation; de novo lipogenesis (DNL); pan-cancer; polo-like kinase 1 (PLK1); ubiquitin conjugating enzyme E2 C (UBE2C)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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