Room-Temperature CuI-Catalyzed N-Arylation of Cyclopropylamine.
J Org Chem
; 89(1): 57-67, 2024 Jan 05.
Article
en En
| MEDLINE
| ID: mdl-38109271
ABSTRACT
A general and efficient CuI/N-carbazolyl-1H-pyrrole-2-carbohydrazide catalyst system was developed for the N-arylation of cyclopropylamine using aryl bromides at room temperature. Herein, 5 mol % CuI and 5 mol % of the ligand were used to synthesize N-aryl cyclopropylamines in moderate to excellent yields. This protocol was scaled up to produce the desired product at gram levels and has been generalized for C-N coupling between aryl bromides and amines at room temperature.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos