Enantioselective α-Amination of Amides by One-Pot Organo-/Iodine Sequential Catalysis.
Org Lett
; 26(1): 258-263, 2024 Jan 12.
Article
en En
| MEDLINE
| ID: mdl-38157251
ABSTRACT
An one-pot organo- and iodine sequential catalysis strategy for reactions of amides with pyrazole-based primary amines was described to synthesize chiral α-amino amides with a quaternary stereocenter. This methodology exhibited strong asymmetric induction, resulting in a typical enantiomeric excess value exceeding 99% and diastereoselectivity up to >991 dr. Moreover, the reaction was conducted without the use of any metals or strong bases.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos