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Causal relationship between human blood metabolites and risk of ischemic stroke: a Mendelian randomization study.
He, Menghao; Xu, Chun; Yang, Renyi; Liu, Lijuan; Zhou, Desheng; Yan, Siyang.
Afiliación
  • He M; The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
  • Xu C; Hunan University of Chinese Medicine, Changsha, Hunan, China.
  • Yang R; Changde College of Science and Technology, Changde, Hunan, China.
  • Liu L; Hunan University of Chinese Medicine, Changsha, Hunan, China.
  • Zhou D; The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
  • Yan S; The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Front Genet ; 15: 1333454, 2024.
Article en En | MEDLINE | ID: mdl-38313676
ABSTRACT

Background:

Ischemic stroke (IS) is a major cause of death and disability worldwide. Previous studies have reported associations between metabolic disorders and IS. However, evidence regarding the causal relationship between blood metabolites and IS lacking.

Methods:

A two-sample Mendelian randomization analysis (MR) was used to assess the causal relationship between 1,400 serum metabolites and IS. The inverse variance-weighted (IVW) method was employed to estimate the causal effect between exposure and outcome. Additionally, MR-Egger regression, weighted median, simple mode, and weighted mode approaches were employed as supplementary comprehensive evaluations of the causal effects between blood metabolites and IS. Tests for pleiotropy and heterogeneity were conducted.

Results:

After rigorous selection, 23 known and 5 unknown metabolites were identified to be associated with IS. Among the 23 known metabolites, 13 showed significant causal effects with IS based on 2 MR methods, including 5-acetylamino-6-formylamino-3-methyluracil, 1-ribosyl-imidazoleacetate, Behenoylcarnitine (C22), N-acetyltyrosine, and N-acetylputrescine to (N (1) + N (8))-acetate,these five metabolites were positively associated with increased IS risk. Xanthurenate, Glycosyl-N-tricosanoyl-sphingadienine, Orotate, Bilirubin (E,E), Bilirubin degradation product, C17H18N2O, Bilirubin (Z,Z) to androsterone glucuronide, Bilirubin (Z,Z) to etiocholanolone glucuronide, Biliverdin, and Uridine to pseudouridine ratio were associated with decreased IS risk.

Conclusion:

Among 1,400 blood metabolites, this study identified 23 known metabolites that are significantly associated with IS risk, with 13 being more prominent. The integration of genomics and metabolomics provides important insights for the screening and prevention of IS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Idioma: En Revista: Front Genet Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Idioma: En Revista: Front Genet Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza